Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease
Identifieur interne : 002688 ( Main/Exploration ); précédent : 002687; suivant : 002689Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease
Auteurs : G. Bellomo [Italie] ; L. Santambrogio [Italie] ; M. Fiacconi [Italie] ; M. Scarponi [Italie] ; G. Ciuffetti [Italie]Source :
- Journal of Neurology [ 0340-5354 ] ; 1991-02-01.
Abstract
Summary: Plasma profiles of prolactin, growth hormone, adrenocorticotropic hormone (ACTH) and cortisol were evaluated in a group of untreated patients with idiopathic Parkinson's disease and a group of healthy age-matched controls. Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idopathic Parkinson's disease, which can affect pituitary function.
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DOI: 10.1007/BF00319704
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Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idopathic Parkinson's disease, which can affect pituitary function.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Bellomo, G" sort="Bellomo, G" uniqKey="Bellomo G" first="G." last="Bellomo">G. Bellomo</name></noRegion><name sortKey="Ciuffetti, G" sort="Ciuffetti, G" uniqKey="Ciuffetti G" first="G." last="Ciuffetti">G. 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